Detailed locus information, expression profile, gene disruption strategy, and phenotype assay data.
| Species | Cryptococcus neoformans var. grubii H99 | ||||||||||||
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| Gene Annotation | adenylate cyclase | ||||||||||||
| Gene Symbol | CAC1 | ||||||||||||
| Phosphatase Name | N/A | ||||||||||||
| Phosphatase Class | Metallo-dependent phosphatase | ||||||||||||
| KEGG Linkout | KEGG::CNG03670 | ||||||||||||
| Genome Browser | JBrowse link goes here. | ||||||||||||
| Protein Domain / KEGG Annotation |
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| Amino Acid Sequence | MSIPLYLLPCLAFHLPSYFSFHFPSIWSQLERLTCAIRMPMFRRSASSHSTSDAAAPPTITNVTEGSPVSSGSITRQKRSRSHGGGGSPASTFSSRFGISRHLSHQFQQPHEQEQGQVPPPEKPATREVPVSLEPEIYGSEAGEDSNFGQEPAGEQLIPETRSSSRQSRRSSRELSVQTIEPSSDDEIRSPEKRRVSPLMKRLGEEPPFMLPHPSLSDSTYQAYPGVVIGSFAGGGPDTLFGNGMQLEGTVDDILDPNAARQEDRGNQVPAGANIAPWLMDDGPPSRSENPSPALSETQERPVKGPAAALREKDPRKTSTVLNHFSSVPSLPKIRRHGRAATTTPDQTPRGSTHSQSNLASSSSSLNNESRESRAGSDDSIQTTLTQKGRRQSPGEWGQASAVPPPSKGTRPGRFGSTASIISGTGSVGEKKKSLFGGLLKRKTNPNLSLNPISHDFTTSEHRGSAGSIPLSASSSKLSSCSLSSLPSKSPPFTSPPEAFSRQFLPANYVHEGAVSPLQEISESPFHLDMNLDDMEGIIDPAKAGLPSTVAYRPSASSEVTTDSSASESMRLEEALNQTSSFGTSVSGASRGSDGTKMPGRIVLGEAERLPTPFTGTDPFQQHRESASTTGSDGKPFSPPSPHTLSPKHHLPSSSANQPRRPSALRNVETGQVDETPQLSASEGSIQPISPSWAGGSGITVFNDPFSTSRQRQEQPPNSAGLSPSTTAYPSAVTQPGPSTARFLITAGSTTPSAAWAAPESWGVEADEAPAEEITSSDEDDWAGLGVEEVASASPTSDTLPSPPTSPRASSLPSPKRAPPFGFKSQQRAKPGTSGTTDSTTSAAGRRKGKRVGSSGRPATGRPGTSGSAYNPSSLHWIRIYRADKSYMLYNLPLNTSTGELLALLAAQAEQGMVRGKNVAINMKLYICERGQNRMLLPSEKPLTIQHRRLLQLGHTEADHLDELGKNDMAVLCRFIYQAPILPIMDPEEESSYDSFEFIDIASRDLQTIPIFLHLHAHDIIILNISKNPMTDIPLDFIQACTSLKELRMSNMALKRVPISIRASTTLARLDVSCNRIADLESVALHEVETLVSLKVQNNKLTSMPSYFAQMKSLKYLNISNNKFETFPSVVCEMSNLVDLDVSFNNIAELPAKMSDLKSLEKLGLYSNDISKFPESFCTLANLRILDVRRNKITDLSAVYALPNLATLQADNNNIVTLDAQLGANVRQFSVPHNSVTRFTLAPPPNMAVVTYMLTNLDLSHGKISTLADEAFSGLTNLVTLNLNFNQFTKLPATLGRLTSLEVFSCTDNMLNLVPAGFGKLQRLRMINLHNNNLKSLPEDLWACGALEVFNASSNLLDSFIPPPADIESVVGRVGSGTSQTSNGRKKYSVPPIGLSIRKLFLADNRLNDDVFHWISLMPSLRIINLSFNDIYEVPPFTLCKCERLEALYLSGNKLTNLPSEDLEKLQSLKVLHLNGNKLQTLPSELGAIKTLQHLDVGSNVLKYNIANWPYDWNWNWNTSLRYLNLSGNKRLEIKPTSAHEMSHASSFRKELSDFTALTQLRVLGLMDVTLRIPSLPDESEEKRVRTSFSDINNMAYGISDMLGSIDNLAMFDLVVPHFRGKENECLFGMFGRVTTTLQGGKIAKYVQEIFAETLTAHLHQLEPGEEPSEALRRTFLLGDRKAFEFFSDKLQLEKERKPSWTSFASFDSMFRGWTPGVNSVLRTGASGAVVYLVDKVLHVGSIGDTLVVLSRKGDAELLSKRHDPTDREESARIRKAEAWVSTKGFVNDDKDLDISRAFGYWHECPAVNAAPEIRTRRLQESDEFVIIGNHALWQFCSYQTAVDIARTERDDPMMAAQKLRDFAISYGAEGNVMVMVVNVSDLFLAKGGRARGPSKQTATDANADVEGYAVAKRQVRRRYDEVGDRTLNRLQQEIEPPVGQVAIVFTDIVNSTHLWETNPAMPTAIKMHHNLMRRQLRLDGGYEVKTEGDSFMVSFQSVASALLWSFNCQIGLLQQEWPRELLEAHDGKVVYDSNGTIVQRGLRVRMGVHWGAPECEKDPITRRMDYYGPMVNRAARINASADGGQLMASQDVLNEIAPLMEYLNSSDEQVLNDLQGDLKREVMELRRIGLEVRDMGDRKLKGLEVPERLHLLYPKTLAGRLEISNEIRAEVEVNDARKSAERQRSVDIDQVYQLSDIALRLEAVCCYNPTPSSPGDTPTAGVMRLHPPASYLGPSIREDMNDEELWTIIESLVGRIENVMSTLYLKNFGEFSAVLAALESATKIDQKLIVHALALMNEAMGKDEENAI | ||||||||||||
| Notation | Condition | Normalized Raw Expression |
|---|---|---|
| A | YPD 30°C, concentration: 2x 10^8 cells/ml | 17681 |
| B | YPD 30°C, concentration: 5x10^7 cells/ml | 6716 |
| C | YPD 30°C, fluconazole treatment, concentration: 5x10^7 cells/ml | 7572 |
| D | YPD 30°C, SDS 0.01% treatment, concentration: 5x10^7 cells/ml | 4391 |
| E | YPD 37°C, concentration: 5x10^7 cells/ml | 3748 |
| F | YP+galactose 30°C, concentration: 2x10^8 cells/ml | 15086 |
| Primer Name | Description | Primer Sequence |
|---|---|---|
| L1 | CNAG_03202 5' flanking region primer 1 | TTCTCCATTCCTACCGTGCG |
| L2 | CNAG_03202 5' flanking region primer 2 | CTGGCCGTCGTTTTACCCGCAAAAGAACCAATGACTAC |
| R1 | CNAG_03202 3' flanking region primer 1 | GTCATAGCTGTTTCCTGATGTGGAAGGATACGCCGTTGC |
| R2 | CNAG_03202 3' flanking region primer 2 | TCAATCCTCCCCACTAAGC |
| SO | CNAG_03202 diagnostic screening primer, pairing with B79 | AGTCTGTCAAAGTCCTCACG |
| PO1 | CNAG_03202 Southern blot probe primer 1 | CTCCACCCACTATCACAAAC |
| PO2 | CNAG_03202 Southern blot probe primer 2 | CCGATGTTCAGAGGTTGTAAAG |
| STM | NAT#159 STM primer | ACGCACCAGACACACAACCAG |
| STM common | STM common primer | GCATGCCCTGCCCCTAAGAATTCG |
| Growth | |
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| Mating Data | |
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| Virulence Factor Production | |
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Capsule ![]() Urease ![]() Melanin ![]() | |
| Stress Response and Adaptation | |
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Osmotic Stress ![]() Oxidative Stress ![]() Heavy Metal Stress ![]() Cell Wall Stress ![]() ER Stress ![]() Genotoxic Stress ![]() | |
| Antifungal Drug Susceptibility | |
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| Virulence Data by the Insect Host Model (Galleria mellonella) | |
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| Lung Infectivity Data by the Signature-tag Mutagenesis-based Murine Host Model | |
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